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TUTORIAL SESSIONS
You are
invited to organize the tutorial sessions for general public or for
special interest groups. For the moment, we have received the
following proposals:
Topic 1:
Computational Surgery
Topic 2: Recent Advances in Computer Modeling in Biomechanics
Topic 3: Multimodal Imaging
Topic 4: Lab-On-A- Chip - Applied Micro and Nanotechology in Life
Sciences
Topic
5:
Introduction to Ultrasound Physics, Instrumentation and Applications
Topic 1:
COMPUTATIONAL SURGERY
Main organizers:
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Barbara Lee Bass, M.D.
John F. and Carolyn Bookout Distinguished Endowed
Chair The Methodist Hospital Department of Surgery,
Executive Director - Methodist Institute for Technology
Innovation and Education (MITIE), Professor of Surgery -
Weill Cornell Medical College - The Methodist Hospital
www.methodisthealth.com,
www.mitietexas.com
Marc Garbey, PhD,
Professor University of Houston
www.cs.uh.edu/~garbey
Roger Tran Son Tay, PhD
Professor University of Florida
www.mae.ufl.edu/cellmech
Scott Berceli,
MD, PhD,
Associate Professor of Surgery, Department of Surgery University of
Florida,
Chief of Vascular Surgery, Veteran Hospital, Gainsville.
http://www.surgery.ufl.edu/Research/berceli.asp |
Duration:
3-4 hours
Who should
attend:
Surgeons, Computer Scientists, and
Computer, Mechanical, Electrical and Biomedical Engineers.
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Brief
Description |
Computational surgery is dedicated to bring together Computational
Science & Surgery Science to form a new generation of high-tech
medical practice in surgery.
The future of surgery is intrinsically linked to the future of
computational sciences: the medical act will be computer assisted at
every single step, from planning to post-surgery recovery, through
the surgery operation itself.
Looking back at the recent history of surgery, surgery practice has
been rapidly revolutionized by the extensive use of medical imaging,
laparoscopy, endoscopy, sensors and actuators, robots etc… This
trend depends highly on computer processing, computational method
and very soon virtualization.
Computational surgery will not only improve the efficiency and
quality of surgery, but will also give new access to very complex
operations that require extreme precision and minimum intrusion.
Such examples are today’s inoperable cancer tumors who have invaded
critical tissues or nervous centers. In order for this milestone to
be reached quicker and more efficiently, surgeons will have to
become very familiar with computing method, such as image analysis,
augmented reality, or robotic. It will be critical for them to
assimilate in their training the way computers work, understand the
limitations/advantages of these computer tools, and be able to
interpret computer imaging and simulations.
The goal of this tutorial and workshop is to discuss the state of
the art of computational surgery and discuss future trends and open
problems. |
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Talk1: MITIE - The Methodist Institute for Technology, Innovation
and Education: A platform to integrate science, surgery and
technology – Barbara Bass –
Talk 2: Breast conserving surgery for breast cancer: targets for
improvement – Barbara Bass –
Talk3: Computational Framework and Image Base Simulation of Breast
Conservative Therapy – Marc Garbey –
Talk4: Hemodynamics and Vascular Remodeling: Computational Biology
as a Discovery Tool - Scott Berceli
Talk5: Emerging Mechanisms of Vein Graft Failure: The Dynamic
Interaction of Hemodynamics and the Vascular Response to Injury –
Roger Tran Son Tay
Talk 6: IMED a Computational Desk for Surgeons – M Garbey. |
Topic 2: RECENT ADVANCES in COMPUTER
MODELING in BIOMECHANICS
Main
organizer:
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Professor Marie-Christine Ho Ba Tho, Universite de
Technologie de Compiegne, France |
Duration:
4 hours
Who should
attend:
Orthopaedic Surgeons, computer and mechanical engineers, biomedical
engineers.
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Brief
Description |
Computer modeling is commonly used to evaluate bone and joints
disease. The objectives are to get a better comprehension of the
bone and joint deformities and to perform an optimised planification
of surgical or orthopaedic treatment. The tutorial will address
recent advances in methods of computer modeling for the development
of in vivo patient specific numerical models derived from medical
imaging technique.
Computer modelling demonstrations will be performed and patient case
will be addressed. |
Topic 3: Multimodal
Imaging
Main
organizers:
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Professor Adam Anderson, Vanderbilt
University, USA
Professor Wellington Pham, Vanderbilt University, USA
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Duration:
3-4 hours
Who should
attend:
Imaging scientists,
radiologists, cognitive scientists, computer scientists, and
biomedical engineers.
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Speaker 1 |
Professor Wellington Pham, Vanderbilt University, USA |
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Brief
Description |
FUNDAMENTALS OF MOLECULAR PROBE DESIGN AND APPLICATIONS
Besides their formal presentations in the Molecular Imaging
forum, Dr. Wellington Pham and Dr. Michael Nickels both from
Vanderbilt University Institute of Imaging Science offer a
tutorial session on the design, synthesis and applications
of multimodal molecular probes for imaging. The aims of the
tutorial is to provide the audiences a cutting edge
methodology on the design and application of contrasting
agents for optical, nuclear (PET, SPECT) and MR imaging. We
hope this lecture offers audiences a unique opportunity to
obtain thorough information of this emerging technology from
theory to practical applications.
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Speaker 2 |
Professor Adam Anderson, Vanderbilt
University, USA |
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Brief
Description |
Practical aspects of
diffusion MRI studies of the brain
Diffusion MRI is the
primary method for assessing white matter integrity and
reconstructing fiber pathways in the living brain. This tutorial
will discuss practical issues in the design of imaging protocols and
analysis of the resulting image data. Advantages and disadvantages
of various MRI pulse sequences for image acquisition will be
discussed. Image artifacts and strategies for mitigating their
effects will be described. Alternative models for fitting the
diffusion data will be compared. The major approaches to fiber
tractography will be discussed. Finally, strategies for voxel-based
and fiber-based comparisons between individuals will be discussed. |
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Speaker 3 |
Professor Anna-Liisa Brownell, Harvard
University Medical School, USA |
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Brief
Description |
FUNDAMENTALS OF PET IMAGING
The tutorial lecture
includes three main topics, which are the base of PET imaging. First
part includes general outlines of PET instrumentation development
including factors effecting resolution and sensitivity of the
radioactivity detection. The second part includes outlines of
radiopharmaceutical development for PET imaging. The third part
includes applications with the focus on optimization of PET
technology and radiopharmaceuticals to the specific research
question. We hope that this tutorial will provide deep insight of
the fundamentals of PET imaging techniques for the audience
interested in in vivo imaging studies. |
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Speaker 4 |
John C. Gore, Ph.D. Director, Vanderbilt University Institute of
Imaging Science |
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Brief
Description |
CANCER IMAGING BIOMARKERS
Imaging plays an important role in the diagnosis,
characterization and management of cancer. Multiple different
imaging techniques have been developed and applied to studies of
human cancers as well as tumor models in animals, and quantitative
imaging biomarkers play an increasingly important role in the
assessment of novel therapies. Considerable efforts are currently
aimed at the development of improved imaging methods for the
detection and evaluation of tumors, for identifying important
characteristics of tumors such as the expression levels of cell
surface receptors that may dictate what types of therapy will be
effective, and for evaluating their response to treatments. In
principle, multiple anatomic, metabolic, physiological and molecular
measurements can be obtained for each voxel within a tumor volume,
providing a multi-parametric, spatially-resolved, three dimensional
characterization of the tumor and its environment. Some imaging
techniques depict specific cellular and molecular markers of
disease, while others report on more general features such as cell
density, blood flow and metabolism which are not specific hallmarks
of cancer. For example, dynamic contrast enhanced magnetic resonance
imaging (DCE-MRI) provides information on vascular properties and
angiogenesis, while diffusion weighted MRI provides quantitative
assessments of tissue cellularity. Magnetic resonance spectroscopy (MRS)
can be used to map key metabolites including choline and lactate, as
well as pH; microPET can depict proliferation (via FLT), metabolism
(via FDG) and hypoxia (via CuATSM or FMISO); while microSPECT can be
used to assess apoptosis using e.g. Annexin-V, all at similar scales
of resolution. Optical and ultrasound molecular imaging methods may
also play useful roles in characterizing specific processes and
targets, such as the increased expression of epidermal and vascular
endothelial growth factors. Using novel, advanced methods for
co-registration between modalities and imaging sessions, these
multiple data sets can be integrated and analyzed on a voxel by
voxel basis to provide a comprehensive overview of tumors, and to
investigate correlations between different measurements of tumor
phenotype.
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Topic 4: LAB-ON-A- CHIP - APPLIED MICRO AND NANOTECHOLOGY IN LIFE SCIENCES
Main
organizers:
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Dr Dang Duong Bang
Senior scientist,
Head of Laboratory of Applied Micro-Nanotech (LAMINATE), National Veterinary Institute, Technical University of Denmark.
http://www.vet.dtu.dk
Dr Anders Wolff
Associated Professor, BIOLABCHIP group Department of Micro
and Nanotechnology, Technical University of Denmark.
http://www.Nanotech.dtu.dk |
Duration: 4 hours
Who should
attend: Medical doctors, Biomedical Engineers, Molecular Biologists, Chemists; Biologists, Pharmaceutical scientists, Veterinary doctors, etc..
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Speaker 1 |
Dr Dang Duong Bang |
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Brief
Description |
A
trip from a tube to a chip- Application of
Micro-nanotechnology in life sciences
More than 200 known diseases are transmitted via
foods or food products. In the United States, food-borne diseases
are responsible for 76 million cases of illness, 32,500 cases of
hospitalisation and 5000 cases of death yearly. The ongoing increase
in worldwide trade in livestock, food, and food products in
combination with increase in human mobility (business- and leisure
travel, emigration etc.) will increase the risk of emergence and
spreading of such pathogens. There is therefore an urgent need for
development of rapid, efficient and reliable methods for detection
and identification of such pathogens.
Microchipfabrication has had a major impact on electronics and is
expected to have an equally pronounced effect on life sciences. By
combining micro-fluidics with micromechanics, micro-optics, and
microelectronics, systems can be realized to perform complete
chemical or biochemical analyses. These so-called 'Lab-on-a-Chip'
will completely change the face of laboratories in the future where
smaller, fully automated devices will be able to perform assays
faster, more accurately, and at a lower cost than equipment of
today. A general introduction of food safety and applied
micro-nanotechnology in life sciences will be given. In addition,
examples of DNA micro arrays, micro fabricated integrated PCR chips
and total integrated lab-on-a-chip systems from different National
and EU research projects being carried out at the Laboratory of
Applied Micro-Nanotechnology (LAMINATE) group at the National
Veterinary Institute (DTU-Vet) Technical University of Denmark and
the BioLabchip group at the Department of Micro and Nanotechnology (DTU-Nanotech),
Technical University of Denmark (DTU), Ikerlan-IK4 (Spain) and other
partners from different European countries will be presented. |
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Speaker 2 |
Dr Cao Cuong, Technical University of Denmark
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Brief
Description |
Micro and Nano particles for Analysis
o cellular and Biomolecular recognitions
Recently, micro and nano-particles have attracted a great
interest in fabrication of various biosensor systems for
analysis of cellular and biomolecular recognitions. In
conjunction with vast conjugation chemistry available, the
materials are easily coupled with biomolecules such as
nucleic acids, antigens or antibodies in order to achieve
their many potential applications as ligand carriers or
transducing platforms for preparation, detection and
quantification purposes. Furthermore, the micro-
nanoparticles possess easily tuned and unique optical/
physical/ chemical characteristics, and high surface areas,
making them ideal candidates to this end. This topic will
addresses basic properties and benefits of gold
nanoparticles (AuNPs) and other microparticles: Sensing
mechanisms based on localized surface plasmon resonance (LSPR),
particle aggregation, catalytic property, and Fluorescence
Resonance Energy Transfer (FRET) of AuNPs as well as
barcoding technologies including DNA biobarcodes and barcode
microparticles will be discussed. Every fundamental
mechanism will be demonstrated with a typical application in
clinical diagnosis. |
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Speaker 3 |
Prof. Dr H. Morgan,
University of Southampton, UK |
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Brief
Description |
Encoded Microparticles for high throughput
multiplexed suspension assays
The requirement for the
analysis of large numbers of biomolecules for drug discovery and
clinical diagnosis has driven the development of low-cost, flexible
and high throughput methods for simultaneous detection of multiple
molecular targets in a single sample (multiplexed analysis). The
technique that most likely satisfies these demands is the
multiplexed suspension (bead—based) assay, which offers a number of
advantages over alternative approaches such as ELISAs and
microarrays. In a bead-based assay, different probe molecules are
attached t different beads, which are then reacted in suspension
with the target sample. After reaction the beads need to be
identified to determine the attached probe molecule, and thus each
bead must be labelled or encoded in some way with a unique
identifier. This lecture discusses some state of the are encoding
methods and provides examples of how encoded particle technologies
are being developed for fast multiplexed assays in a microfluidic
format. |
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Speaker 4 |
Assoc. Prof. Dr. Nam-Trung Nguyen,
Nanyang Technological University |
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Brief
Description |
Lab on a chip-DNA Bare code
The requirement for the analysis of large numbers of biomolecules
for drug discovery and clinical diagnosis has driven the development
of low-cost, flexible and high throughput methods for simultaneous
detection of multiple molecular targets in a single sample
(multiplexed analysis). The technique that most likely satisfies
these demands is the multiplexed suspension (bead?based) assay,
which offers a number of advantages over alternative approaches such
as ELISAs and microarrays. In a bead-based assay, different probe
molecules are attached t different beads, which are then reacted in
suspension with the target sample. After reaction the beads need to
be identified to determine the attached probe molecule, and thus
each bead must be labelled or encoded in some way with a unique
identifier. This lecture discusses some state of the art encoding
methods and provides examples of how encoded particle technologies
are being developed for fast multiplexed assays in a microfluidic
format. |
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Speaker 5 |
Assoc. Prof. Dr. Anders Wolff |
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Brief
Description |
A total
integrated biochip system for Detection of SNP in Cancer
Cancer is a leading cause of death worldwide. Resistance
of tumor cells to radiation and chemotherapy is the major obstacle
in cancer treatment. The serious toxicity that follows the
administration of certain drugs can be associated with Single
Nucleotide Polymorphisms (SNPs) of genes involved in drug metabolism
and can ultimately reduce the clinical efficacy of chemotherapy. The
KRAS and TP53 genes are altered in many human tumors. K-RAS point
mutation appear early in the tumorigenesis pathway and can therefore
be used for early cancer detection. The functional inactivation of
p53 by point mutation is a hallmark of many tumors.
Importantly, most anticancer agents act by inducing apoptosis and,
typically, p53-deficient tumors are more resistant to druginduced
apoptosis than those carrying wild-type p53. It is therefore
important to analyze such SNPs and point mutation
in cancer diagnosis and treatment. In this paper, we described a
total integrated BIOLABCHIP namely SMART-BioMEMS for rapid detection
and identification SNPs of Kirsten-RAS (Kras) and TP53 genes in
cancer. The SMART-BioMEMS system consist of different components: An
optical readout system, disposable biochip; and a reusable actuators
chip that can perform all the steps from sample preparation, DNA
isolation and purification, PCR amplification, Enzymatic clean up,
mini-sequencing and SNP detection. The prototype of the SmartBIOMEMS
system designs, detail of different components and functions will be
present and discusses. It is results of great cooperation in the FP6
EU project SMARTBioMEMS. |
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Next speakers |
Prof.
Dr. Jan Dziuban
Talk: “Detection of Metrological signals in
Lab-on-a-chips”
Dr. Ruano Jesus Miguel,
IKERLAN S.COOP, Mondragon
Spain
Talk: ”New insight of Micro-fabrication
technologies”
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Topic
5: Introduction To
Ultrasound Physics, Instrumentation and Applications
Main
organizers:
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Lawrence H. Le, PhD, MBA.
Associate professor of
Medical Physics, Department of Radiology and Diagnostic Imaging,
University of Alberta, Edmonton, AB, Canada, T6G 2B7;
Also in Diagnostic Imaging
Services, Alberta Health Services, Edmonton, Alberta, Canada.
www.phys.ualberta.ca/~lale
Pascal Laugier,
PhD
Director
Laboratoire d'Imagerie Paramétrique UMR CNRS Université Pierre et
Marie
Curie-Paris 6 France
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Duration: 2 hours
Who should
attend:
Anyone who is interested in
ultrasound principles and some of its applications in medicine and
biomedical research is welcome.
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Brief
Description |
Ultrasound has increasingly become a modality of
choice for many clinical applications mainly because of its lack of
radiation, portability, and less cost. This tutorial will provide a
brief description of physical principles governing sound wave
propagation and modern ultrasound instrumentations. The tutorial
will be concluded by presenting some developed and mostly recent
ultrasound applications in medicine and biomedical research. |
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